Book: Phosphoinositide 3-kinase in Health and Disease: Volume 1
Author: Christian Rommel, Bart Vanhaesebroeck, and Peter K. Vogt
Pages: 280
Format: PDF
Language: English
ISBN10: 3642136621
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
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